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Vi-CELL BLU Cell Viability Analyzer

The faster Vi-CELL BLU automates the Trypan Blue Dye Exclusion method for cell viability analysis. The Vi-CELL BLU expedites processing by now having the option to use a 24-position sample carousel or a 96 well plate for sample delivery.

Additional enhancements incorporated in the Vi-CELL BLU include:

Fully automated sample preparation, analysis and post-run cleaning
Small sample size
Fast sample processing time
Small laboratory footprint
Flexible sample introduction – carousel or 96 well plate
User-friendly reagent system
Cell viability reported in percentage, concentration, and cell count
Large sample capacity
Data integrity tools

Want more information? Watch the Vi-CELL BLU Launch video.

Vi-CELL BLU Cell Viability Analyzer Features

Increased Productivity

FAST mode
24-position carousel
Supports 96 well plate sample introduction
Customizable analysis parameters

Flexibility and Ease of Use

Easy sample vial dispensing
Easy load reagent pak
Load on the go processing
Clean room kit option

Improved Reagent Pack

RFID Tracking of reagent part number, lot number, activities, and expiration date
Easy load for automated sample prep
Reagent pack complete with Trypan Blue dye, buffer, disinfectant and cleaning solutions

Data Integrity and Compliance

Audit trail
Error log files
Electronic signature capability
Secure user sign-on
User level permissions
Administrative configuration tools
IQ/OQ

Introducing the Vi-CELL BLU

Vi-CELL BLU Cell Viability Analyzer Specifications

Industry Standards	21 CFR Part 11
Sample Volume Range	0.20\|\|mL
Particle Size Analysis Range	2.00\|60.00\|μm
Sample Volume	200.00\|µL
Concentration Range	50,000.00\|15,000,000.00\|cells/mL

Item Specifications Referenced

C19201

Documentation

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Title	Description
Vi-CELL BLU Zellanalysator Broschüre {A7DF4F56-8AF9-4BF1-88BE-766AB73FBC6B}
Vi-CELL BLU Cell Viability Analyzer Brochure {A7DF4F56-8AF9-4BF1-88BE-766AB73FBC6B}	Product brochure for the New VI-CELL BLU Cell Viability Analyzer. See what BLU can do for you
Manufacturing Processes for Engineered T-Cell Therapy – CAR-T {749D68FB-4893-4B2D-BD6C-C662F0520F64}	Brochure presenting the CAR-T cell therapy workflow and associated product portfolio
Manufacturing Processes for Engineered T-Cell Therapy – CAR-T	Brochure presenting the CAR-T cell therapy workflow and associated product portfolio
Quality Control Testing Instrumentation Solutions for GMP Manufacturing Brochure {A7DF4F56-8AF9-4BF1-88BE-766AB73FBC6B}	Brochure on Raw Materials QC, Production QC, and Final Product QC product solutions
Evaluation of Instrument to Instrument Performance of the Vi-CELL BLU Cell Viability Analyzer {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note examines the comparability of results from multiple Vi-CELL BLU cell viability analyzers.
Vaporized Hydrogen Peroxide Decontamination of Vi-CELL BLU Instrument {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note demonstrates the method and results for testing the Vi-CELL BLU for VHP resistance.
Matching Cell Counts between Vi-CELL XR and Vi-CELL BLU {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note explains the flexibility to adjust the cell type settings to match results obtained from an equivalent sample when run on the Vi-CELL XR on the Vi-CELL BLU.
ViCELL BLU and ViCELL XR Specifications	The Vi–CELL BLU leverages the key performance features of the Vi–CELL XR but incorporates many design improvements that our customers have requested over the years. This paper highlights the differences in specifications between the two instruments.
Method for Determining Cell Type Parameter Adjustment to Match Legacy Vi-CELL XR {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note assists in matching Vi-CELL BLU cell types to give cell counts and viability levels equivalent to those obtained on existing Vi-CELL XR instruments.
Cell Counting Performance of Vi-CELL BLU Cell Viability Analyzer {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note examines how the new Vi-CELL BLU performs within specifications so that any instrument variability can be eliminated from the sample measurement.
Considerations of Cell Counting Analysis when using Different Types of Cells {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note reviews several different cell types and cell preparation approaches using standard cells.
Vi-CELL BLU FAST Mode Option {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note explains the optional FAST Mode of operation in the new Vi-CELL BLU which can be used in either plate or carousel configuration to significantly reduce sample to sample operation times.
Vi-CELL BLU Regulatory Compliance - 21 CFR Part 11 {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	The following document describes the relevant portions of the 21 CFR Part 11 regulations and their implementation using the Vi-CELL BLU control software.
21 CFR Part 11 QC Instrument Suite {279C6CA2-9797-4CFE-9CAA-5EAFAC29B60D}	This datasheet outlines QC steps, instruments, applications, regulations, and ALCOA compatibility.
ALCOA+ Infographic	Guidance on Maintaining Data Integrity Infographic
Cell Counting Performance of Vi–Cell BLU Cell Viability Analyzer {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	To determine the cell counting performance of the Vi–CELL BLU we adapted the protocol outline by NIST to determine the performance of the new Vi–Cell BLU Cell Viability Analyzer.
Vaporized Hydrogen Peroxide Decontamination of Vi–CELL BLU Instrument <br> {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Whole instrument decontamination is desirable in many laboratories and necessary in some when using biologically hazardous materials. By necessity such methods are chemically aggressive in nature and can cause serious damage to electronic and optical systems. The Vi–CELL BLU Cell Viability Analyzer was tested for VHP resistance. This paper outlines the method and results.
Matching Cell Counts between Vi–CELL XR and Vi–CELL BLU {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	<p>This paper demonstrates a series of different cell types run on the Vi-CELL XR and duplicate samples run on the Vi-CELL BLU. The cells were then reanalyzed adjusting the cell type parameters until a new cell type was generated that gave cell concentrations within +/–5%* and viable cell density levels within +/–2.5%* of the Vi-CELL XR. </p> <ol> </ol>
Specification Comparison of Vi–CELL XR and Vi–CELL BLU {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	The Vi–CELL BLU leverages the key performance features of the Vi–CELL XR but incorporates many design improvements that our customers have requested over the years. This paper highlights the differences in specifications between the two instruments.
Vi–CELL BLU FAST Mode Option<br> <br> {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This paper explains the optional FAST Mode of operation in the Vi-CELL BLU cell viability analyzer which can be used in either plate or carousel configuration to significantly reduce sample to sample operation times. <br>
Vi-CELL BLU Regulatory Compliance - 21 CFR Part 11 {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	The following information describes the relevant portions of the 21 CFR Part 11 regulations and their implementation using the Vi-CELL BLU control software.
Method for Determining Cell Type Parameter Adjustment to Match Legacy Vi CELL XR {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note details how you can use the plate loader feature on the Vi-CELL BLU to match cell types to give cell counts and viability levels equivalent to those obtained on existing Vi-CELL XR instruments.
Considerations of Cell Counting Analysis when using Different Types of Cells {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This paper reviews several different cell types and cell preparation approaches using standard cells, such as, CHO cells, EL4 cells, SF9 cells, and HELA cell cultures.
FDA ALCOA Guidance	21 CFR part 11 ALCOA defines good data integrity practice as creating records that are attributable to the technician carrying out the testing, are legible, are created contemporaneously, original and accurate.
Evaluation of Instrument to Instrument Performance of the Vi-CELL BLU Cell Viability Analyzer {442DF88C-CA7F-4B78-AF75-9D2B985534C0}

Vi-CELL BLU Cell Viability Analyzer

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Cell Type Guidelines

Features

Software

Reagents

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Vi-CELL BLU Cell Viability Analyzer Features

Increased Productivity

Flexibility and Ease of Use

Improved Reagent Pack

Data Integrity and Compliance

Introducing the Vi-CELL BLU

Vi-CELL BLU Cell Viability Analyzer Specifications

Documentation

Technical Documents

Related Parts

Vi-CELL BLU Reagent Kit

Vi-CELL BLU Quad Pak (Qty 4)

Vi-CELL BLU 10.0M Single-Use Concentration Control (25 Vials)

Vi-CELL BLU 4.0M Single-Use Concentration Control (20 Vials)

Vi-CELL BLU 2.0M Single-Use Concentration Control (20 Vials)

Vi-CELL BLU 0.5M Single-Use Concentration Control (20 Vials)